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The events of the game more closely follow the events of Venom's first limited series, Venom: Lethal Protector. Of particular note is that the title is misleading – the plot of the comic book series Venom: Separation Anxiety involves Venom's five symbiote spawn attempting to force Eddie (without his symbiote) to help them communicate with their own symbiotes. There is also cameo assistance from Captain America, Ghost Rider, Hawkeye, and Daredevil. The game boasts a large number of thugs that the player has to defeat: heavily armed Jury and Venom's symbiote children.
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Venom/Spider-Man: Separation Anxiety is a side-scrolling beat 'em up video game and sequel to Spider-Man and Venom: Maximum Carnage, released for Sega Mega Drive and Super NES and then ported to PC, in which one or two players could team up as Spider-Man and Venom to defeat the evil symbiote Carnage.
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